THE ACTION OF ACETYL-BETA-METHYLCHOLINE CHLORIDE (MECHOLYL) IN NEUROGENIC DISTURBANCES OF THE URINARY BLADDER, WITH A NOTE ON THE MECHANISM OF SPINAL SHOCK

¹ From the Sub-Department of Neurology, The Johns Hopkins University

The action of Mecholyl was tested in cats having lesions of the posterior sacral roots, of all the sacral roots, and of the spinal cord (either at lower lumbar or at upper thoracic levels).

Satisfactory contraction of the detrusor muscle, with evacuation of the bladder, occurred when only the sensory innervation of the bladder was interrupted, or when the animal had recovered from the stage of shock following motor lesions. Mecholyl failed to produce vesical contraction during the period of shock after neural injury.