THE LOCAL ANESTHETIC ACTIONS OF TWO ESTERS OF MONO ALKYLATED AMINO ALCOHOLS

¹ From the Department of Physiology and Pharmacology, Long Island College of Medicine and Department of Chemistry, Polytechnic Institute, Brooklyn, New York

The toxicity and anesthetic efficiency of two esters of mono alkalated amino alcohols, monocaine and amylcaine, were determined upon a number of different test animals.

It was found that monocaine was a very effective compound in producing infiltration and conduction anesthesia. Although it was about one and one-half times as toxic as procaine, its anesthetic efficiency was many times greater. It was able to produce sciatic nerve block in the non-anesthetized guinea pig in concentrations as low as 1/64 per cent.

Amylcaine, although also capable of producing nerve block in low concentrations appeared to be more efficient in effecting anesthesia when applied topically, as to the cornea of the rabbit's eye. The presence of erosions following the administration of this compound was less frequent than in the case of the other anesthetics.