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Journal of Pharmacology And Experimental Therapeutics, Vol. 62, Issue 1, 39-53, 1938
Copyright © 1938 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF DRUGS USED IN SPINAL ANAESTHESIA

KENNETH BULLOCK 1 and A. D. MACDONALD 1

1 From the Department of Pharmacy and Pharmacology, The University of Manchester

1. The literature dealing with the estimation of the concentration of local anaesthetics in body tissues, and the fate of such drugs when administered by intrathecal injection is reviewed.

2. A suitable technique for the estimation of local anaesthetics derived from para-amino-benzoic acid in cerebro-spinal fluid, blood and urine is described.

3. In spinal anaesthesia in the cat the concentration of drug rapidly falls at the point of injection. Little is present at any time in the blood, and little is excreted in the urine. The spread upwards from the point of injection is very limited.

4. Figures are given relating the average duration of anaesthesia with the concentration of drug injected.

Submitted on July 21, 1937






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Copyright © 1938 by the American Society for Pharmacology and Experimental Therapeutics.