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1 From the Department of Pharmacology, Cornell University Medical College, New York City
A preparation is described, consisting of the isolated papillary muscle from the cat, which affords satisfactory material for the study of the action of drugs on mammalian cardiac muscle.
The digitalis glucosides, ouabain and digitoxin, in concentrations approximating those obtaining in the body following the administration of therapeutic quantities of these drugs, bring about a several-fold increase in systolic tension.
There is thus demonstrated a direct action of digitalis bodies in increasing the force of cardiac muscle, independent of any effects which might be mediated through other influences on the intact heart. Shortening of the muscle fiber (decrease in diastolic size) is not essential to the explanation of the action of digitalis in increasing the force of contraction of the failing mammalian heart.
Submitted on August 2, 1937
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