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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 4, 440-450, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES VII. COMPOUNDS DERIVED FROM CODEINE AND DIHYDROCODEINE BY SUBSTITUTION IN THE 6-CARBON POSITION

CHARLES I. WRIGHT 1 and FLEMING A. BARBOUR 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Four alkaloids derived from dihydrocodeine by substitutions in the 6-carbon position were all more effective respiratory depressants than dihydrocodeine. Four similar substitutions in the codeine molecule however did not consistently increase the potency of the parent alkaloid.

The effect of hydrogenating codeine and its derivatives in the 6-7 or 7-8 carbon positions is not predictable if judged by the seven instances studied.

Substitution of a methoxyl group for the 3-carbon phenolic hydroxyl of morphine and its derivatives decreased the respiratory depressant action in each of fifteen instances.

Submitted on July 21, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.