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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 4, 422-439, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES VI. COMPOUNDS DERIVED FROM MORPHINE AND DIHYDROMORPHINE BY SUBSTITUTION IN THE 6-CARBON POSITION

CHARLES I. WRIGHT 1 and FLEMING A. BARBOUR 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Substitution of chemical groups for the 6-carbon hydroxyl of morphine or dihydromorphine increased the respiratory depressant action in each of the twelve instances studied. The substituted alkaloids are not of equal potency and there are some variations in the rate of increase in potency with increasing dosage.

Hydrogenation in 6-7 or 7-8 carbon positions of the derivatives of morphine had no significant effect on the potency in six cases, caused a definite decrease in two, an increase in two and an increase only at the higher dose range in one. Therefore, the results of such hydrogenation are not predictable.

Submitted on July 21, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.