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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 4, 412-421, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION OF ADMINISTERED IODIDE AND THIOCYANATE IN COMPARISON WITH CHLORIDE IN PATHOLOGICAL TISSUES, AND THEIR RELATION TO BODY FLUIDS

G. B. WALLACE 1, B. B. BRODIE 1, MAX M. FRIEDMAN 1, and DAVID BRAND 1

1 From the Department of Pharmacology, New York University College of Medicine

1. The distribution of iodide in tuberculous, syphilitic and tumor tissues, and in cystic and transudate fluids has been determined, and compared to that of chloride and thiocyanate.

2. As with normal tissues it was found that the relative concentration in terms of tissue/blood or tissue/serum ratio was alike for the three substances.

3. The conclusion is reached that here as in normal tissues, iodides and also thiocyanates are distributed practically entirely in extracellular fluid.

4. The similarity of distribution of iodide, chloride and thiocyanate renders improbable a selective chemical or physical relationship of iodide to pathological tissues.

Submitted on July 19, 1937






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