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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 4, 321-327, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE HYDROLYSIS OF ACETANILIDE BY VARIOUS TISSUES

HARRY O. MICHEL 1, FREDERICK BERNHEIM 1, and MARY L.C. BERNHEIM 1

1 From the Departments of Biochemistry, Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. Acetanilide is hydrolyzed by various tissues into acetic acid and aniline.

2. The preparation and properties of the enzyme responsible for the hydrolysis are described.

3. There is indirect evidence that aniline in the presence of tissue can be oxidized to p-aminophenol.

Submitted on July 16, 1937




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