THE CHEMOTHERAPY OF EXPERIMENTAL STREPTOCOCCUS INFECTIONS OF RABBITS WITH SPECIAL REFERENCE TO PYRIDINE COMPOUNDS AND PRONTOSIL SOLUBLE

¹ From the Research Institute of Cutaneous Medicine, Philadelphia

1. Since septicemia due to hemolytic streptococci is usually due to a rapid overflow of organisms into the blood from a primary infection of the fixed tissues which cannot be effectively balanced by the clearing mechanism, the primary purpose of treatment is to provide adequate drainage whenever possible supplemented by such biologic and chemotherapeutic measures as will aid disinfection of the fixed tissues, the blood and the clearing mechanism.

2. For these reasons we have mainly employed rabbits with experimentally produced local skin lesions and suppurative arthritis with septicemia, permitting direct clinical observations and bacteriological examinations for evidences of disinfection and clearing.

3. The results of a comparative study of 8 compounds is reported. Particularly encouraging results have been observed with 2 pyridine compounds containing an amino group or an amino group with iodine and especially with 2-2' pyridyl sulphide di-hydrobromide, since the effects have been similar to those observed with "prontosil solution" in similar amounts per kilogram of weight.

4. From a comparative study of compounds having a pyridine nucleus with those having a benzene nucleus, it would appear that the former offers greater possibilities than the latter and particularly when containing divalent sulfur in the molecule.

This article has been cited by other articles:

				J. A. KOLMER PROGRESS IN CHEMOTHERAPY OF BACTERIAL AND OTHER DISEASES: WITH SPECIAL REFERENCE TO THE PRONTOSILS, SULFANILAMIDE AND SULFAPYRIDINE Arch Intern Med, April 1, 1940; 65(4): 671 - 743. [Abstract] [PDF]