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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 3, 218-229, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HISTAMINE ON SALIVARY SECRETION

O. S. GIBBS 1 and H. H. McCLANAHAN 1

1 Pharmacology Department, University of Tennessee, Memphis, Tennessee

1. Intra-arterial injections of acetyl choline produce regular salivary secretion which endures exactly as long as the injection.

2. Histamine administered in the same way may, or may not produce a secretion.

3. A histamine secretion once started tends to continue as long as histamine is administered.

4. A histamine secretion is potentiated by physostigmine and obliterated by atropine.

5. Intra-arterial administration of histamine causes marked potentiation of the effects of chorda stimulation. It has no such effect on intra-arterially administered acetyl choline.

6. The mechanism of histamine secretion is discussed and it is suggested that this depends on histamine producing a continuation of the effects of a stimulus of the cholinergic nerves.

Submitted on May 28, 1937






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