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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 2, 196-204, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION OF SULFANILAMIDE IN THE ORGANISM

E. K. MARSHALL JR. 1, KENDALL EMERSON JR. 1, and W. C. CUTTING 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

In the dog, after administration of the drug, sulfanilamide is present in approximately equal concentrations in the various tissues with the exception of bone and fat. The distribution ratio, i.e., the ratio of the concentration of the drug in the whole organism to the concentration in the blood has been determined in 6 dogs. This ratio appears to be higher in man than in the dog. Simultaneous determinations of sulfanilamide in blood and spinal fluid of man during several hours administration of the drug show that the concentration in the spinal fluid is parallel to and slightly lower than in the blood.

Submitted on June 26, 1937




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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.