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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 2, 134-138, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

HYDROLYSIS OF SALTS OF BARBITURIC ACIDS AS RELATED TO THE RATE OF ONSET OF ANESTHESIA

MILTON T. BUSH 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

The apparent ionization constants of the hypnotics phenobarbital, barbital, amytal, pentobarbital and evipal have been determined. From these the hydrolysis of the sodium salts, and the acid-salt ratios at the pH of blood have been estimated. These values are such that there is no apparent correlation between them and the rate of onset of the anesthesia.

Submitted on May 26, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.