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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 2, 121-129, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF STAPHYLOCOCCUS AUREUS EXOTOXIN ON THE RABBIT HEART

J. H. DINGLE 1, H. E. HOFF 1, L. H. NAHUM 1, and B. W. CAREY JR. 1

1 From the Laboratory of Physiology, Yale University School of Medicine, and the Department of Bacteriology and Immunology, Harvard University Medical School

1. The exotoxin of Staphylococcus aureus, titrated for its dermonecrotic and haemolytic activity, was injected intravenously into eight normal and three anesthetized rabbits in varying doses.

2. Frequent electrocardiograms were taken from lead II, and in the three anesthetized animals the arterial blood pressure was simultaneously recorded.

3. Death occurred in from 1frac12 to 20 minutes, depending on the dosage. No effect was noted with doses less than 0.062 cc. per kilogram.

4. Collapse and death were preceded by evidence of progressively severe myocardial damage accompanied by venous engorgement.

5. Various rhythmic changes were observed, which had no causal relationship to the fatal outcome.

Submitted on May 24, 1937




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Arch Surg, October 1, 1942; 45(4): 571 - 577.
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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.