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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 1, 10-20, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE ACETYLCHOLINE-CHOLINE-ESTERASE SYSTEM

G. E. HALL 1 and C. C. LUCAS 1

1 Department of Medical Research, Banting Institute, University of Toronto

Using blood sera as the source of enzyme we present data which suggest specificity of the esterase studied, but with Sobotka and Glick (18) (who used liver and pancreatic enzyme) we realize the inability to draw conclusions regarding specificity of esterase merely from a study of the comparative action on a series of esters.

Horse, cat, mouse and guinea-pig sera are very active towards tributyrin and monobutyrin, while rabbit, man, dog and chicken sera are less active. Pig and sheep sera exhibit no hydrolytic activity towards these esters (see graph).

Guinea-pig and horse sera are very active towards methyl butyrate; mouse, cat, rabbit, man, chicken and dog sera are much less so, while pig, ox and sheep exhibit no activity towards methyl butyrate (see graph).

Mouse sera is very active towards acetylcholine: in order of decreasing activity are horse, man, dog, guinea-pig, cat, chicken, rabbit and beaver, with carp, pig, ox and sheep sera having very little, if any, activity towards acetylcholine (see graph).

Fairly wide variations in the activity of the sera towards the different esters are noted within species (table 8).

Submitted on April 5, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.