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Journal of Pharmacology And Experimental Therapeutics, Vol. 61, Issue 1, 1-9, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE INFLUENCE OF VITAMIN C DEFICIENCY UPON THE RESISTANCE OF GUINEA PIGS TO DIPHTHERIA TOXIN GLUCOSE TOLERANCE

A. SIGAL 1 and C. G. KING 1

1 From the Department of Chemistry, University of Pittsburgh

The glucose tolerance test was used to study the effect of different levels of vitamin C intake on the carbohydrate disturbance in guinea pigs caused by diphtheria toxin. The degree and duration of dysfunction was influenced to a significant degree by the state of nutrition of the animals. Sublethal injections of toxin caused a greater disturbance in animals receiving only enough vitamin to prevent scurvy, compared to those receiving a more generous supply. It is evident from the data presented that the level of vitamin C intake for optimum in vivo detoxification of diphtheria toxin is considerably greater than that necessary to protect from scurvy or to show a favorable growth rate.

Submitted on April 1, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.