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Journal of Pharmacology And Experimental Therapeutics, Vol. 60, Issue 4, 472-486, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

PICROTOXIN AS A RESPIRATORY STIMULANT

E. K. MARSHALL JR. 1, EDWARD M. WALZL 1, and D. H. LEMESSURIER 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University

1. Picrotoxin is very effective in reinstating respiration which has failed under phenobarbital from carotid sinus inactivation and from overdosage with chlorbutanol, paraldehyde or "avertin fluid." It is less effective against overdosage with urethane and useless against overdosage with ethyl alcohol.

2. Strychnine is ineffective under the above conditions, coramine is only slightly better, while metrazol is frequently effective in large dosage but inferior to picrotoxin.

3. In anesthetized animals, picrotoxin usually stimulates respiration in non-convulsive doses, while in normal dogs or decerebrate dogs and cats no stimulation of respiration occurs from injection of picrotoxin unless convulsive doses are given.

Submitted on April 1, 1937




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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.