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Journal of Pharmacology And Experimental Therapeutics, Vol. 60, Issue 3, 235-244, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

RETICULOCYTOSIS IN THE GUINEA PIG I. THE USE OF STANDARD GUINEA PIGS IN THE ASSAY OF ANAHAEMIN

M. M.O. BARRIE 1

1 From the Physiological Laboratories of The British Drug Houses Limited, London

1. Guinea pigs show individual variations in reticulocytosis.

2. The mean value about which reticulocytosis varies in guinea pigs is not the same in all groups of animals.

3. The mean reticulocyte value for any set of guinea pigs is not the same in different stocks and the differences may be due to the degree of immunity to disease, or may be characteristic of the strain of guinea pig.

4. In a set of 100 animals from the same stock as the 230 tested, a mean degree of reticulocytosis which differs from that of the latter by more than 30 per cent can be detected.

5. A method of assay for liver preparations is suggested.

Submitted on January 27, 1937






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