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Journal of Pharmacology And Experimental Therapeutics, Vol. 60, Issue 2, 228-233, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF MORPHINE AND ITS DERIVATIVES ON CONTRACTIONS OF LEECH MUSCLE DUE TO ACETYL-CHOLINE, CHOLINE AND NICOTINE

J. H. QUASTEL 1 and M. TENNENBAUM 1

1 From the Biochemical Laboratory, Cardiff City Mental Hospital

1. Morphine inhibits reversibly the contractions of eserinized leech muscle due to acetyl-choline.

2. An approximately constant ratio exists between the amounts of morphine present in the medium and the minimum quantities of acetyl-choline necessary to give a contraction in presence of them.

3. The following morphine derivatives—heroin, codeine, dionine—behave similarly to morphine, heroin being a more powerful inhibitor than morphine and codeine and dionine less powerful inhibitors. Apomorphine is inactive as an inhibitor of acetyl-choline contraction.

4. Morphine also inhibits reversibly the contractions of noneserinized leech muscle due to choline and nicotine.

5. Narcotine, papaverine and cotarnine have no definite inhibitive actions on acetyl-choline contractions of leech muscle in the concentrations tested.

Submitted on February 14, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.