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Journal of Pharmacology And Experimental Therapeutics, Vol. 60, Issue 1, 89-95, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE DIURETIC ACTION OF THE OXYTOCIC HORMONE OF THE PITUITARY GLAND AND ITS EFFECT ON THE ASSAY OF PITUITARY EXTRACTS

A. M. FRASER 1

1 From the Department of Medicine, McGill University Clinic, Royal Victoria Hospital, Montreal

1. Postlobin-O, administered subcutaneously, increases urine output in hydrated and non-hydrated rats.

2. The diuretic action of postlobin-O is not due to the pressor hormone contaminating it.

3. Pitocin produces a diuretic effect in non-hydrated rats equal to that of postlobin-O.

4. Postlobin-O antagonizes the antidiuretic action of postlobin-V. Therefore, the rat antidiuretic assay method is only of value when the ratio between oxytocic and pressor activities of the standard preparation is similar to that of the unknown preparation.

Submitted on January 15, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.