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Journal of Pharmacology And Experimental Therapeutics, Vol. 59, Issue 4, 451-457, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE SYNERGIC CALORIGENIC ACTIONS OF EPINEPHRINE AND DINITROPHENOL

V. E. HALL 1 and P. E. CHAMBERLIN 1

1 From the Department of Physiology, Stanford University, California

In anesthetized cats the increase in oxygen consumption rate caused by dinitrophenol is markedly greater if epinephrine be infused intravenously at a physiological rate during, or just before, the period of dinitrophenol action. The enhancement so produced is significantly greater than the increase in oxygen consumption yielded by epinephrine alone. This synergic calorigenic action is a major factor in the enhancement of dinitrophenol metabolic stimulation observed in hypothermic animals.

Submitted on February 2, 1937






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.