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Journal of Pharmacology And Experimental Therapeutics, Vol. 59, Issue 4, 429-436, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

PEPTONE SHOCK

CARL A. DRAGSTEDT 1 and FRANKLIN B. MEAD 1

1 From the Department of Physiology and Pharmacology, Northwestern University Medical School, Chicago, Illinois

1. Peptone shock in dogs is accompanied by the appearance of a vasodepressor substance which is detectable in the blood and occasionally in the thoracic duct lymph.

2. The vasodepressor substance has been tentatively identified as histamine.

3. The theory that peptone shock in dogs is produced indirectly by the liberation of a vasodepressor substance from the tissues is advanced and shown to be more compatible with the general characteristics of the reaction than the assumption that peptone is inherently a toxic substance.

Submitted on January 4, 1937




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 Arch Intern MedHome page
R. C. ROBERTS, K. A. CROCKETT, and T. C. LAIPPLY
EFFECTS OF SALICYLATES AND BENADRYL ON EXPERIMENTAL ANAPHYLACTIC HYPERSENSITIVE VASCULAR AND CARDIAC LESIONS
Arch Intern Med, January 1, 1949; 83(1): 48 - 66.
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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.