JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 59, Issue 4, 401-412, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

LOCAL ANAESTHETICS DERIVED FROM THE ALKALOID CYTISINE

H. RAYMOND ING 1 and R. P. PATEL 1

1 From the Department of Physiology, Pharmacology and Biochemistry, University College, London

1. Seven N-alkyl ester derivatives of cytisine have been tested for toxicity and local anaesthetic activity.

2. Four of them compared favourably with cocaine on the rabbit's cornea and two of them compared favourably with cocaine on intradermal injection in man.

3. One of them (CPB) was tested for the typical nicotine properties of cytisine, which proved to be absent.

It is a pleasure to record our thanks to Professor J. H. Gaddum for much help and advice and to Dr. H. Rydin who made the intradermal injections. We also wish to make acknowledgments to the Alembic Chemical Works, Baroda, for a loan to one of us (R.P.P.).

Submitted on December 20, 1936






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Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.