THE ANTISYMPATHOMIMETIC ACTION OF DIOXANE COMPOUNDS (F883 AND F933), WITH SPECIAL REFERENCE TO THE VASCULAR RESPONSES TO DIHYDROXYPHENYL ETHANOLAMINE (ARTERENOL) AND NERVE STIMULATION

¹ Department of Pharmacology, McGill University, Montreal

It is shown that the dioxane compounds, F883 and F933, exert similar antisympathomimetic effects when tested upon the blood pressure of the chloralosed dog or cat with adrenaline and arterenol.

Unlike the action of adrenaline, that, of arterenol is not reversed after injection of these substances. The rise of blood pressure produced by splanchnic nerve stimulation is also not inverted.

No essential differences could be detected between the antisympathomimetic actions of these compounds and that of ergotamine.

These data lend confirmation to earlier reported results from this laboratory using ergotamine and thus support further the possibility that arterenol may be the physiological chemical mediator (substance M of Cannon and Rosenblueth) of sympathetic nerve endings.