JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ROEPKE, M. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ROEPKE, M. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 59, Issue 3, 264-276, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF CHOLINE ESTERASE

M. H. ROEPKE 1

1 Department of Pharmacology, University of Toronto

1. The dissociation constants of the enzyme-substrate-complex for choline esterase have been determined for acetylcholine, acetylarsenocholine and butyrlcholine as substrates.

2. Choline, arsenocholine, acetyl-beta-methylcholine, tetramethylammonium chloride, tropine, l-hyocyamine, d-hyocyamine, atropine, NaCl, KCl and NH4Cl are competitive inhibitors of choline esterase. The dissociation constants of the enzyme-inhibitor-complex have been determined for these compounds.

3. The inhibition of the esterase by carbamylcholine, physostigmine and prostigmine is discussed.

4. The question of the use of choline esterase as a model for the cell receptors is discussed in connection with theories on the mode of action of the choline-like compounds.

Submitted on October 27, 1936






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1937 by the American Society for Pharmacology and Experimental Therapeutics.