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Journal of Pharmacology And Experimental Therapeutics, Vol. 59, Issue 1, 48-53, 1937
Copyright © 1937 by American Society for Pharmacology and Experimental Therapeutics

THE ESTROGENIC ACTIVITIES OF SOME SYNTHETIC PHENANTHRENE COMPOUNDS AND SOME OXIDATION PRODUCTS OF THEELOL

SIDNEY A. THAYER 1, D. W. MACCORQUODALE 1, and EDWARD A. DOISY 1

1 From the Laboratory of Biological Chemistry, St. Louis University School of Medicine, St. Louis

1. Thirty-two phenanthrene derivatives have been assayed for estrogenic activity and of these 9-ethylphenanthrene, 1-keto-1,2,3,4-tetrahydrophenanthrene and 2-phenanthreneacetic acid gave a positive response when injected into mice at a dosage of 25 mgm.

2. The acid, C18H22O5, and other similar oxidation products of theelol are considerably less active than theelin but much more potent than the synthetic phenanthrene derivatives studied in this investigation.

Submitted on August 24, 1936






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