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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 4, 439-453, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE PROPERTIES OF THE PHYSIOLOGICALLY ACTIVE SUBSTANCE IN THE BODY RESULTING FROM THE ADMINISTRATION OF ACETYL-BETA-METHYLCHOLINE CHLORIDE BY IONTOPHORESIS

W. F. ALEXANDER 1 and A. J. KOTKIS 1

1 From the Departments of Micro-anatomy and Internal Medicine, St. Louis University School of Medicine

1. A substance is present in the perfusate from the limb of the experimental animal after the iontophoresis of acetyl-beta-methylcholine chloride which in its physiological action is identical with that of the uniontophorized compound.

2. This substance is present in the perfusate in the concentration of the order of one part in 1 x 106 as is shown by the tests on the cat.

3. Iontophoresis with normal saline solution produces only negative results.

4. The substance present in the perfusate can be recovered and concentrated, so that it will produce physiological actions identical with those of a known concentration of acetyl-beta-methylcholine chloride, namely, drop in blood pressure, positive inotropic and negative chronotropic effects on the heart, salivation, in some instances urination and in other instances increased bronchial secretion.

5. The effect of the active substance present in the perfusate is abolished by atropine sulphate.

6. The cation of ABMCC is stable and the substance present in the perfusate is similar to acetyl-beta-methylcholine chloride.

Submitted on August 6, 1936






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