JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ETTELDORF, J. N.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ETTELDORF, J. N.
Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 4, 431-438, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

ON THE DETOXIFICATION OF GASEOUS HYDROCYANIC ACID

JAMES N. ETTELDORF 1

1 Pharmacology Department, University of Tennessee, School of Biological Sciences, Memphis, Tennessee

1. Dogs, rabbits, chickens, white rats, and guinea pigs were exposed to known concentrations of gaseous hydrocyanic acid for long periods.

2. The critical level for various animals has been measured and is shown by the onset of convulsions.

3. Below the critical level hydrocyanic acid is efficiently dealt with by the detoxifying mechanism for an unlimited time.

4. There is no evidence of tolerance or increased susceptibility.

5. Methylene blue has but little value as a treatment for cyanide poisoning above the critical level.

6. Methylene blue has considerable value as a prophylactic against concentrations of hydrocyanic acid above the critical level.

Submitted on August 3, 1936






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.