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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 4, 417-427, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF CHRONIC MORPHINE POISONING IN DOGS VI. EFFECT OF INCREASING TISSUE OXIDATIONS BY DINITROPHENOL ON THE EXCRETION OF MORPHINE IN TOLERANT AND NON-TOLERANT DOGS

O. H. PLANT 1 and D. SLAUGHTER 1

1 From the Laboratory of Pharmacology, State University of Iowa, Iowa City, Iowa

1. The increase in cellular metabolism that follows the administration of small doses of dinitrophenol markedly decreases the excretion of morphine in non-tolerant dogs, but does not materially modify the excretion of the alkaloid in tolerant animals.

2. These findings confirm the results obtained in recovery of morphine from the tissues and indicate that the mechanism by which morphine is handled by the tissues of tolerant dogs differs from that in non-tolerant animals.

Submitted on August 1, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.