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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 3, 294-304, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF COFFEE AND DECAFFEINATED COFFEE ON OXYGEN CONSUMPTION, PULSE RATE AND BLOOD PRESSURE

KATHRYN HORST 1, ROBERT J. WILLSON 1, and RALPH G. SMITH 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

In 26 experiments on 14 human subjects under basal conditions in which oxygen consumption was measured before decaffeinated coffee was taken and one-half hour and one and one-half hours after, little, if any, change was found following the beverage in the majority of cases. In an equal number of experiments on the same subjects in which coffee (equivalent to 4 mgm. per kilogram of caffeine) was taken, a definite increase in oxygen consumption was recorded for both periods following the drinking of the beverage (one-half hour period, +8 per cent; one and one-half hour period, +9 per cent).

In the same experiments, decaffeinated coffee produced negligible and inconstant changes on pulse rate and blood pressure whereas coffee, in the majority of instances produced a slight decrease in pulse rate and a slight rise in blood pressure.

Submitted on July 22, 1936




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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.