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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 3, 286-293, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE STUDIES WITH THE THYROTROPIC HORMONE

W. KENNETH CUYLER 1, BENJAMIN F. STIMMEL 1, and D. ROY McCULLAGH 1

1 Department of Biochemical Research, Cleveland Clinic, Cleveland, Ohio

The details of the assay Of thyrotropic hormone from the anterior lobe of the pituitary gland are presented. Using a relatively crude preparation of the hormone, three doses of 4 milligrams each were found to decrease only slightly the iodine content of the thyroid glands of twenty-one-day-old rats. Three doses of 1 milligram each caused a marked effect in 200-gram guinea pigs whereas three doses of only 0.025 milligram each were necessary to accelerate the rate of metamorphosis in the frog tadpole.

Submitted on July 16, 1936




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 Arch Intern MedHome page
R. W. RAWSON and P. STARR
DIRECT MEASUREMENT OF HEIGHT OF THYROID EPITHELIUM: A METHOD OF ASSAY OF THYROTROPIC SUBSTANCE; CLINICAL APPLICATION
Arch Intern Med, May 1, 1938; 61(5): 726 - 738.
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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.