STUDIES OF PHENANTHRENE DERIVATIVES VII. A COMPARISON OF ANALAGOUS PHENANTHRENE AND DIBENZOFURAN DERIVATIVES

¹ From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Definite analgesic action can be elicited in cats with compounds formed by the addition of suitable substituents to a dibenzofuran nucleus.

A comparison of parallel series of compounds where the same substituent is combined with phenanthrene or with dibenzofuran shows that greater analgesic effect is produced with the latter. However, the dibenzofuran derivatives are more toxic, as a rule, than the corresponding derivatives of phenanthrene so that the relation between analgesic and toxic doses is about the same in both series.

In regard to other effects there is a striking parallelism in many instances in the results obtained by the attachment of the same side-chain to either the dibenzofuran or the phenanthrene nucleus.