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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 2, 128-134, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON BARBITURATES XVIII. ANALYSIS OF A PERIPHERAL ACTION OF BARBITURATES

CHARLES R. LINEGAR 1, JAMES M. DILLE 1, and THEODORE KOPPANYI 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University, School of Medicine, Washington, D. C.

Amytal, pernoston and pentobarbital in moderate doses, and barbital in large doses may paralyze the peripheral vagus, whereas phenobarbital has no paralytic effects.

The central vagus is not paralyzed even after massive doses of barbiturates.

The administration of pilocarpine and acetylcholine slows the heart in animals in which the peripheral vagus function has been abolished by barbiturates.

The administration of physostigmine may not have a spontaneous effect on the heart rate but restores the excitability of the vagus abolished by barbiturates.

It is concluded that the locus of barbiturate action in the vagus is in the peripheral ganglionic cells of the heart.

Submitted on June 1, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.