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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 1, 62-67, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE LOCAL ANAESTHETIC ACTIVITY OF QUINOLINE COMPOUNDS

H. K. SINHA 1

1 From the Department of Pharmacology, University of Edinburgh

My results, combined with those of Bovet, show that a large number of quinoline compounds with a basic side chain of adequate length in position 8 produce a strong local anaesthetic action, both when applied to mucous membranes and when injected intradermally. My results also show that side chains with two amine groups are more effective than side chains containing a single amine group.

Submitted on May 22, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.