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Journal of Pharmacology And Experimental Therapeutics, Vol. 58, Issue 1, 105-110, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE SYNERGISM AND ANTAGONISM OF DRUGS II. THE ACTION OF PHYSOSTIGMINE ON AUTONOMIC GANGLIA

THEODORE KOPPANYI 1, JAMES M. DILLE 1, and CHARLES R. LINEGAR 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University, School of Medicine, Washington, D. C.

The administration of physostigmine abolishes the vagal (parasympathetic) paralysis produced by nicotine or curare.

The administration of physostigmine abolishes the sympathetic paralysis produced by nicotine.

The ganglionic paralytic effect of nicotine and curare exerted in the autonomic system is opposed by physostigmine, but not by pilocarpine.

Atropine prevents the ganglionic effect of physostigmine.

An explanation is offered for this ganglionic "stimulant" effect of physostigmine.

Submitted on June 1, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.