JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by BERNHEIM, F.
Right arrow Articles by BERNHEIM, M. L. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BERNHEIM, F.
Right arrow Articles by BERNHEIM, M. L. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 57, Issue 4, 427-436, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

ACTION OF DRUGS ON THE CHOLINE ESTERASE OF THE BRAIN

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From the Departments of Physiology and Pharmacology, and Biochemistry, Duke University School of Medicine, Durham, North Carolina

1. The preparation and properties of the choline esterase of the brain are described.

2. In most animals the activity of choline esterase per milligram of dry weight is greater in the brain than in the serum.

3. Choline esterase is greatly inhibited by very small concentrations of morphine and apomorphine.

4. It is suggested that these two drugs and possibly other centrally acting drugs may cause the accumulation of acetylcholine in the brain by inhibiting the choline esterase.

Submitted on May 11, 1936




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
L. LASAGNA
NALORPHINE (N-ALLYLNORMORPHINE) Practical and Theoretical Considerations
Arch Intern Med, October 1, 1954; 94(4): 532 - 558.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.