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Journal of Pharmacology And Experimental Therapeutics, Vol. 57, Issue 3, 253-257, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ACID ON THE GUINEA PIG ILEUM CONTRACTED BY ACETYLCHOLINE AND HISTAMINE

JAMES W. SACHS 1 and JOSEPH McK. IVIE 1

1 From the Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. Approximately twice the amount of acetic acid is needed to relax an intestinal strip when contracted by acetylcholine than when contracted by histamine.

2. The amount of acid necessary to cause relaxation is dependent within limits on the amount of histamine but independent of the amount of acetylcholine used.

3. Lactic acid has the same effect as acetic acid.

4. Increasing the calcium concentration has no effect on the acid relaxation.

Submitted on March 14, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.