JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DEBEER, E. J.
Right arrow Articles by HJORT, A. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by DEBEER, E. J.
Right arrow Articles by HJORT, A. M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 57, Issue 1, 19-33, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIVE HYPNOTIC EFFECTS OF SOME ARYL AND UNSYMMETRICAL ALKYLARYL THIOUREAS

EDWIN J. DEBEER 1, JOHANNES S. BUCK 1, WALTER S. IDE 1, and AXEL M. HJORT 1

1 From the Burroughs Wellcome and Company, U. S. A., Experimental Research Laboratories, Tuckahoe, N. Y.

1. Sixty aryl and unsymmetrical alkylaryl thioureas were synthesized for examination of hypnotic potency. Fifty-three were successfully tested in mice.

2. These thioureas uniformly had hypnotic potency, some of a high order.

3. The hypnotic effects of the thioureas improve with increase in molecular weight in homologous series. The maximum effect occurs when the alkyl substituents reach the propyl to amyl groups.

4. The aryl and lower unsymmetrical alkylaryl thioureas are consistently more potent than their urea analogs. The higher alkylaryl thioureas, however, closely resemble in potency the few analogous ureas thus far examined.

Submitted on February 6, 1936






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.