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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 4, 446-450, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE CENTRAL ACTION OF ACETYLCHOLINE

GEORGE A. SILVER 1 and HENRY G. MORTON 1

1 From the Department of Physiology and Pharmacology, Duke Medical School, Durham, North Carolina

1. Acetylcholine in concentrations of 2.0 to 4.0ggr injected into the hypothalamic region of cats anesthetized with urethane caused a small rise in blood pressure followed by a sharp fall lasting one to two minutes. Similar injections into the lateral ventricle gave the same effect, but not so consistently. Control injections of saline were without effect. The fall of blood pressure was still produced after both vagi were cut.

2. Cardiac and respiratory irregularities occurred occasionally.

3. Intraventricular injections of acetylcholine into the unanesthetized cat caused drowsiness which lasted about one hour.

Submitted on January 14, 1936






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