JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GRUBER, C. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GRUBER, C. M.
Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 4, 432-439, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE EFFECTS OF SODIUM ISOAMYLETHYLBARBITURATE (SODIUM AMYTAL) AND OF SODIUM N-HEXYLETHYL BARBITURATE (ORTAL SODIUM) UPON THE INTACT INTESTINE IN THE UNANESTHETIZED DOG

CHARLES M. GRUBER 1

1 From the Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

1. Ortal sodium and sodium amytal decrease the general tonus and the amplitude of the rhythmic contractions of duodenal, jejunal and ileal loops in non-anesthetized dogs.

2. In the intact intestine of the non-anesthetized dog the duration of the decreased tonus and of the amplitude of the rhythmical contraction is less with ortal sodium than with sodium amytal. These findings are the reverse of those previously obtained on excised intestine.

3. High hydrostatic pressure (30 cm. water) within the balloon definitely decreases the speed of recovery of the tissue from the effects of these drugs. In this work pressures of 15 cm. were used in the ileum and jejunum almost entirely and 8 cm. in the duodenum.

Submitted on January 8, 1936






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.