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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 4, 421-431, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF MORPHINE, CODEINE AND THEIR DERIVATIVES XII. THE ISOMERS OF MORPHINE AND DIHYDROMORPHINE

NATHAN B. EDDY 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

The general pharmacological activity of the isomers of morphine and dihydromorphine is described.

In addition the activity of four groups of isomers in the morphine, codeine series, the structural relationships in each group being the same, is discussed in relation to the chemical modifications.

It is suggested that the pharmacological relationships afford a basis for pairing the isomers, a pairing at present impossible by chemical means.

Submitted on January 2, 1936






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.