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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 4, 389-395, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF EPHEDRINE ON ERYTHROCYTES, LEUCOCYTES AND PLATELETS IN THE NORMAL AND SPLENECTOMISED GUINEA PIG

S. LEVY SIMPSON 1 and B. H. E. CADNESS 1

1 From the Pathological Laboratory of the Princess Louise Kensington Hospital for Children

Ephedrine produced a similar increase in the number of erythrocytes, leucocytes and platelets in both normal and splenectomised guinea pigs. The spleen is therefore not essential for these changes in this animal.

In addition to other evidence the disproportionate increase in the different cell elements indicated that "blood concentration" is not an adequate explanation of the changes. Ephedrine probably causes extrusion into the circulation of erythrocytes, leucocytes and platelets from storage and haemopoietic centres, including the bone marrow.

Submitted on November 23, 1935






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