JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GRUBER, C. M.
Right arrow Articles by DENOTE, A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GRUBER, C. M.
Right arrow Articles by DENOTE, A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 3, 284-289, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF METHYL-AMINO METHYL HEPTENE (OCTIN) UPON THE INTACT INTESTINE IN THE NON-ANESTHETIZED DOG

CHARLES M. GRUBER 1, RAYMOND HEILIGMAN 1, and ANTHONY DENOTE 1

1 From the Department of Pharmacology, Jefferson Medical College, Philadelphia, Pennsylvania

1. Octin bitartrate and octin hydrochloride when injected intravenously in a non-anesthetized dog cause loss in the general tonus, decreased force of the rhythmical contractions and decreased peristaltic activity in the Thiry-Vella loop of either the jejunum or ileum and of the duodenum.

2. Equal quantities of either octin or papaverine, when injected produced a decreased tonus but the duration of the effect of the former drug is found to be three to twelve times longer than that of the latter.

3. Octin bitartrate in large doses caused nausea and vomiting in some of the animals studied.

4. Octin causes a temporary fall followed by a prolonged rise in blood pressure.

5. The cardiac stimulating action of octin is similar to that of epinephrine but larger doses are needed.

6. The excised uterus of the rabbit is contracted by octin. The uterus of the non-pregnant cat which is relaxed by adrenalin is contracted by octin.

7. Octin causes slight vaso-constriction of the blood vessels in frogs.

8. The relaxation of bronchial muscle observed with octin was less than that noted with adrenalin.

Submitted on November 25, 1935






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.