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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 2, 188-193, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE TRYPANOCIDAL ACTION OF AZO DYES

A. ST. G. HUGGETT 1 and S. F. SUFFOLK 1

1 Department of Physiology, University of Leeds

1. The effects of certain substances on the trypanosome infection in mice were compared.

2. The substances used were—Germanin, Neoarsphenamine, and the azo dyes chlorazol fast pink BKS, chlorazol sky blue FFS, and the special dye S.D.2.

3. The dyes have a trypanocidal action, the most active being the isomers of afridol violet. Of these chlorazol fast pink BKS when given subcutaneously appears to be only slightly less active than Germanin but it has relatively high toxicity.

Submitted on October 18, 1935






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.