JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SEEVERS, M. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SEEVERS, M. H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 2, 147-156, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

OPIATE ADDICTION IN THE MONKEY I. METHODS OF STUDY

M. H. SEEVERS 1

1 From the Department of Pharmacology of the University of Wisconsin, Madison

Evidence is presented to indicate the superiority of the monkey to other laboratory animals as a test object for the comparative study of addiction to the opium derivatives.

Satisfactory methods of housing, care, and handling for a study of this type are described, and a description of the behavior during addiction and withdrawal is presented. The signs of abstinence are classified according to their order of appearance and relative severity and are compared with the signs and symptoms which occur in the human addict.

Behavior, which we interpret to be the establishment of a positive desire for the drug during abstinence, is described and the factors favoring the formation of such a response in this animal are discussed.

It is believed that the rapid method of addiction with the monkey as a test object, in which the largest doses to be given are attained in a period of two or three weeks, is satisfactory for the determination of the relative addiction potentialities of a series of different opium derivatives, although it does not give quite so clear a differentiation as that following a more prolonged period of poisoning, such as occurs in the human addict.

Submitted on October 17, 1935




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. H. Ko, M. F. Divin, H. Lee, J. H. Woods, and J. R. Traynor
Differential in Vivo Potencies of Naltrexone and 6beta-Naltrexol in the Monkey
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 772 - 779.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. A. Paronis and J. H. Woods
Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal,
J. Pharmacol. Exp. Ther., July 1, 1997; 282(1): 348 - 354.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.