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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 1, 69-76, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS ON THE EFFECTS OF DIHYDROMORPHINONE-HYDROCHLORIDE (DILAUDID) ON THE INTACT UTERUS OF ANIMALS ANESTHETIZED BY CEREBRAL ANEMIA

J. B. MITCHELL JR. 1 and D. S. PANKRATZ 1

1 From the Department of Pharmacology and the Department of Anatomy, University of Tennessee College of Medicine, Memphis

1. Dilaudid causes a brief rise in tonus and a prolonged inhibition in rate and force of contraction of the intact non-pregnant rabbit uterus, the effects occurring separately in some animals.

2. The tendency to produce increased tonus and inhibit contractions decreases with the advance of pregnancy; dilaudid is practically devoid of effect on tonus or movement in the rabbit, cat, or guinea pig uterus near term.

3. No decrease in uterine tonus is found after dilaudid.

4. Increased rate of contraction is noted only during the brief period of increased tonus in a few instances.

5. Fetuses are frequently stimulated to kicking movements in utero by the intravenous injection of large doses of dilaudid into the mother.

Submitted on October 21, 1935






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