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Journal of Pharmacology And Experimental Therapeutics, Vol. 56, Issue 1, 53-59, 1936
Copyright © 1936 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY AND RATE OF DISAPPEARANCE OF INTRACISTERNALLY INJECTED CALCIUM SALTS IN THE DOG

MORTON F. MASON 1 and HARRY RESNIK 1

1 From the Departments of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville

Solutions of calcium chloride, calcium gluconate and calcium lactate containing 0.25 mgm. or less of calcium per kilogram of body weight may be injected intracisternally in dogs without the occurrence of pronounced toxic reactions. Larger doses cause pronounced respiratory depression and 0.40 mgm. of calcium per kilogram of body weight was found to be a lethal dose in all instances. The simultaneous injection of magnesium chloride and calcium chloride did not increase the tolerance of dogs to calcium chloride.

No pronounced differences were found in the rate of disappearance from the cerebrospinal fluid of intracisternally injected calcium chloride, calcium gluconate and calcium lactate, although in some instances the calcium level remained considerably elevated for several hours.

Submitted on October 14, 1935






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Copyright © 1936 by the American Society for Pharmacology and Experimental Therapeutics.