JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by CHEN, K. K.
Right arrow Articles by CHEN, A. L.
Right arrow Search for Related Content
PubMed
Right arrow Articles by CHEN, K. K.
Right arrow Articles by CHEN, A. L.
Journal of Pharmacology And Experimental Therapeutics, Vol. 55, Issue 3, 319-325, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGICAL ACTION OF DENDROBINE. THE ALKALOID OF CHIN-SHIH-HU

K. K. CHEN 1 and A. LING CHEN 1

1 From the Lilly Research Laboratories, Indianapolis, Indiana

Dendrobine, C16H25O2N, has a slight but demonstrable analgesic and antipyretic action—much weaker than that of amidopyrine. It produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure, suppresses the respiration, inhibits isolated rabbits' intestines, and contracts isolated guinea pigs' uteri.

The minimal lethal dose determined by intravenous injection in white mice and rats is 20 mgm. per kilogram, that in guinea pigs 22 mgm., and that in rabbits 17 mgm. per kilogram. Death is preceded by convulsions.

The convulsions caused by dendrobine appear to be central in origin—probably due to the stimulating action on both the medulla and the spinal cord. Sodium amytal has a detoxifying effect on dendrobine.

Submitted on August 11, 1935






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.