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Journal of Pharmacology And Experimental Therapeutics, Vol. 55, Issue 2, 200-205, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

ANTIPYRETIC AND TOXIC EFFECTS OF COMBINATIONS OF ACETANILID WITH SODIUM BROMIDE AND WITH CAFFEINE

PAUL K. SMITH 1 and W. E. HAMBOURGER 1

1 From the Department of Pharmacology and Toxicology, Yale University

The "lethal dose" (i.e., the dose causing death to 50 per cent of treated animals), of sodium bromide in adult albino rats is approximately 3500 mgm. per kilogram of body weight. The "lethal dose" of caffeine is approximately 200 mgm. per kilogram.

Combinations of acetanilid and sodium bromide cause fewer fatalities than if their toxic actions were purely additive. Combinations of acetanilid and caffeine are almost exactly additive in their toxic effects as judged by the "lethal dose."

A combination of acetanilid, sodium bromide, and caffeine given in two different sized doses was much less toxic than predicted on the assumption that their effects were additive.

Sodium bromide slightly antagonizes the antipyretic action of acetanilid.

Caffeine raises the temperature of fevered rats and antagonizes the antipyretic action of acetanilid. Sodium bromide and caffeine together antagonize to a large extent the antipyretic action of acetanilid.

Submitted on July 30, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.