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Journal of Pharmacology And Experimental Therapeutics, Vol. 55, Issue 2, 127-135, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF MORPHINE, CODEINE AND THEIR DERIVATIVES IX. METHYL ETHERS OF THE MORPHINE AND CODEINE SERIES

NATHAN B. EDDY 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Five pairs of compounds of the morphine series are compared in each of which one member differs from the other only in the muzzling of the alcoholic hydroxyl by methylation.

Methylation of the alcoholic hydroxyl like methylation of the phenolic hydroxyl increases toxicity and convulsant action and decreases emetic effect. The former chemical change unlike the latter increases analgesic and exciting effects in the cat and depressant action in the rat.

Submitted on June 17, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.