SEX VARIATION IN THE KETONURIA OF ETHER ANESTHESIA IN RATS

¹ From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Ketonuria in fasting female rats anesthetized with ether is much greater than that of male rats treated similarly, particularly on the third and fourth days of fasting when the resultant ether ketosis is at its height. Subcutaneous injection of epinephrine hydrochloride in divided doses of 0.2 mgm. per kilogram at four-hour intervals did not result in a ketosis in either male or female animals. Thus, if ether ketosis is mediated through stimulation of epinephrine output, this effect must be greater than that obtained by subcutaneous injection of the above doses of epinephrine hydrochloride. Apparently the same mechanisms function in ether ketosis as are present in less obscure ketoses.

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